Thalamocortical axons regulate neurogenesis and laminar fates in early sensory cortex
Nakagawa, Y.; Monko, T.; Rebertus, J.; Stolley, J.; Salton, S. R.
Show abstract
Area-specific axonal projections from the mammalian thalamus shape unique cellular organization in target areas in the adult neocortex. How these axons control neurogenesis and early neuronal fate specification is poorly understood. By using mutant mice lacking the majority of thalamocortical axons, we show that these axons increase the number of layer 4 neurons in primary sensory areas by enhancing neurogenesis and shifting the fate of superficial layer neurons to that of layer 4 by the neonatal stage. Part of these area-specific roles is played by the thalamus-derived molecule, VGF. Our work reveals that extrinsic cues from sensory thalamic projections have an early role in the formation of cortical cytoarchitecture by enhancing the production and specification of layer 4 neurons.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- PlexinA4-Semaphorin3A mediated crosstalk between main cortical interneuron classes is required for superficial interneurons lamination 97%
- A thalamic reticular circuit for head direction cell tuning and spatial navigation 96%
- Topographic connectivity and cellular profiling reveal detailed input pathways and functionally distinct cell types in the subthalamic nucleus 96%
Similar papers in this journal
- Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behavior 96%
- Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations 95%
- Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons 95%
Similar papers in this journal
- Bottom-up inputs are required for the establishment of top-down connectivity onto cortical layer 1 neurogliaform cells 96%
- Mediodorsal and ventromedial thalamus engage distinct L1 circuits in the prefrontal cortex 96%
- Individual thalamic inhibitory interneurons are functionally specialized towards distinct visual features 96%
Similar papers in this journal
- Distinct 'driving' versus 'modulatory' influences of different visual corticothalamic pathways 96%
- Developmental onset of a cerebellar-dependent forward model of movement in motor thalamus 96%
- Spatial constraints and cell surface molecule depletion structure a randomly connected learning circuit 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.