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Bioelectromagnetic platform for stimulation

Ashbaugh, R. C.; Udpa, L.; Israeli, R. R.; Gilad, A. A.; Pelled, G.

2021-06-07 bioengineering
10.1101/2021.06.07.447412 bioRxiv
Show abstract

Magnetogenetics is a new field that utilizes electromagnetic fields to remotely control cellular activity. In addition to the development of the biological genetic tools, this approach requires designing hardware with a specific set of demands for the electromagnets used to provide the desired stimulation for electrophysiology and imaging experiments. Here we present a universal stimulus delivery system comprised of four magnet designs compatible with electrophysiology, fluorescence and luminescence imaging, microscopy, and freely behaving animal experiments. The overall system includes a low-cost stimulation controller which enables rapid switching between active and sham stimulation trials as well as precise control of stimulation delivery.

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