Blocking antibodies against integrin-α3, integrin-αM, and integrin-αMβ2 de-differentiate myofibroblasts and reverse lung and kidney fibroses in a mouse model
WHITE, M.; ozkan, m.; Raczy, M.; Medellin, J. E. G.; Koss, K. M.; Alpar, A. T.; Naved, B. A.; Wertheim, J.; Hubbell, J. A.
Show abstract
Fibrosis is involved in 45% of deaths in the United States, and no treatment exists to reverse the progression of the disease. Myofibroblasts are key to the progression and maintenance of fibrosis. We investigated features of cell adhesion necessary for monocytes to differentiate into myofibroblasts, seeking to identify pathways key to myofibroblast differentiation. Blocking antibodies against integrins 3, M, and M{beta}2 de-differentiate myofibroblasts in vitro, lower the pro-fibrotic secretome of myofibroblasts, and reverse lung and kidney fibrosis in vivo. Decorins collagen-binding peptide directs blocking antibodies (against integrins-3, -M, -M{beta}2) to both fibrotic lungs and fibrotic kidneys, reducing the dose of antibody necessary to reverse fibrosis. This targeted immunotherapy blocking key integrins may be an effective therapeutic for the treatment and reversal of fibrosis. SummaryBlocking antibodies against integrins-3, -M, and -M{beta}2 can be targeted to sites of fibrosis, reverse lung and kidney fibroses, and offer the potential to bring immunotherapy to fibrosis
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation 94%
- Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa 93%
- Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing 93%
Similar papers in this journal
- Interleukin 11 expression causes murine inflammatory bowel disease 95%
- Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy 94%
- Generation and characterization of two immortalized dermal fibroblast cell lines from the spiny mouse (Acomys) 94%
Similar papers in this journal
- Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle 94%
- Soluble ECM promotes organotypic formation in lung alveolar model 94%
- Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model 94%
Similar papers in this journal
- Inhibition of histone readers bromodomain extra-terminal proteins alleviates skin fibrosis in experimental models of scleroderma 94%
- The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix 94%
- PAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.