Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder
Gelegen, C.; Cash, D.; Ilic, K.; Sander, M.; Kim, E.; Simmons, C.; Bernanos, M.; Lamma, J.; Randall, K.; Brown, J.; Kalanj Bognar, S.; Cooke, S.; Chaudhury, K. R.; Ballard, C.; Francis, P.; Rosenzweig, I.
Show abstract
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a rare parasomnia that may predict the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of -synucleinopathy, we now demonstrate striking REM and NREM sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.
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