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Sylites: Multipurpose markers for the visualization of inhibitory synapses

Khayenko, V.; Schulte, C.; Reis, S. L.; Avraham, O.; Schietroma, C.; Worschech, R.; Nordblom, N. F.; Kachler, S.; Villmann, C.; Heinze, K.; Schlosser, A.; Furman-Schueler, O.; Tovote, P.; Specht, C. G.; Maric, H. M.

2021-05-21 neuroscience
10.1101/2021.05.20.444651 bioRxiv
Show abstract

We introduce Sylites - small and versatile fluorogenic affinity probes for high-contrast visualization of inhibitory synapses. Having stoichiometric labeling and exceptional selectivity for neuronal gephyrin, a hallmark protein of the inhibitory post-synapse, Sylites enable superior synapse staining compared with antibodies. Combined with super-resolution microscopy, Sylites allow precise nanoscopic measurements of the synapse. In brain tissue, Sylites reveal the three-dimensional distribution of inhibitory synapses within just an hour.

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