A novel cholinergic neural pathway and its role in the drug relapse
He, T.; Chen, W.; Fan, Y.; Xu, X.; Wang, Z.; Li, N.; Guo, H.; Lu, X.; Ge, F.; Guan, X.
Show abstract
The lateral parabrachial nucleus (LPB) is critical hub implicated in the control of food intake, reward and aversion. Here, we identified a novel cholinergic projection from choline acetyltransferase (ChAT)-positive neurons in external portion of the lateral parabrachial nucleus (eLPBChAT) to {gamma}-aminobutyric acid (GABA) neurons in central nucleus of amygdala (CeAGABA), activation of which could block methamphetamine (METH)-primed conditioned place preference (CPP) in mice.
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