Immune profile of children with post-acute sequelae of SARS-CoV-2 infection (Long Covid)
Di Sante, G.; Buonsenso, D.; De Rose, C.; Valentini, P.; Ria, F.; Sanguinetti, M.; Sali, M.
Show abstract
There is increasing reporting by patients organization and researchers of long covid (or post-acute sequelae of SARS-CoV-2 - PASC), characterized by symptoms such as fatigue, dyspnea, chest pain, cognitive and sleeping disturbances, arthralgia and decline in quality of life. Immune system dysregulation with a hyperinflammatory state, direct viral toxicity, endothelial damage and microvascular injury have been proposed as pathologenic mechanisms. Recently, cohorts of children with PASC have been reported in Italy, Sweden and Russia. However, immunological studies of children with PASC have never been performed. In this study, we documented significant immunologic differences between children that completely recovered from acute infection and those with PASC, providing the first objective laboratory sign of the existence of PASC in children.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- COVID-19 and Multisystem Inflammatory Syndrome in Latin American children: a multinational study 94%
- Infants have lower RT-PCR cycle threshold for SARS-CoV-2 in comparison with older children and adults 93%
- Plasma protein biomarkers distinguish Multisystem Inflammatory Syndrome in Children (MIS-C) from other pediatric infectious and inflammatory diseases 93%
Similar papers in this journal
- More complaints than findings - Long-term pulmonary function in children and adolescents after COVID-19 93%
- Characteristics and outcomes of cases of children and adolescents with pediatric inflammatory multisystem syndrome in a tertiary care center in Mexico City 93%
- One-Year Follow-up of Young People with ME/CFS Following Infectious Mononucleosis by Epstein-Barr Virus 92%
Similar papers in this journal
- Upregulation of Activation Induced Cell Markers (AIM) among Severe COVID-19 patients in Bangladesh 93%
- Long-term T cell perturbations and waning antibody levels in individuals needing hospitalization for COVID-19 92%
- Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology 92%
Similar papers in this journal
- Serology in Children with Multisystem Inflammatory Syndrome (MIS-C) associated with COVID-19 96%
- Durability of SARS-CoV-2 Antibodies from Natural Infection in Children and Adolescents 91%
- Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study 90%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.