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The miR-424/503 cluster modulates Wnt/β-catenin signaling in the mammary epithelium by regulating the expression of the LRP6 co-receptor

Nekritz, E. A.; Rodriguez-Barrueco, R.; Yan, K.-K.; Davis, M. L.; Werner, R. L.; Devis-Jauregui, L.; Mukhopadhyay, P.; Yu, J.; Llobet-Navas, D.; Silva, J.

2021-05-07 cancer biology
10.1101/2021.05.06.442934 bioRxiv
Show abstract

During the female lifetime, the enlargement of the epithelial compartment dictated by the ovarian cycles is supported by a transient increase in the MaSC population. Notably, activation of Wnt/{beta}-catenin signaling is an important trigger for MaSC expansion. Here, we report that the miR-424/503 cluster is a novel modulator of canonical Wnt-signaling in the mammary epithelium that exerts its function by targeting the LRP6 co-receptor. Additionally, we show that the loss of this microRNA cluster is associated with breast cancers possessing high levels of Wnt/{beta}-catenin signaling.

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