Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells
Pagani, I.; Ottoboni, L.; Podini, P.; Ghezzi, S.; Brambilla, E.; Bezukladova, S.; Corti, D.; Bianchi, M. E.; Capobianchi, M. R.; Yates, E. A.; Martino, G.; Vicenzi, E.
Show abstract
Zika virus (ZIKV) is an arbovirus member of the Flaviviridae family that causes severe congenital brain anomalies in infected fetuses. Human neural progenitor cells (hNPCs) are highly permissive to ZIKV infection, causing inhibition of cell proliferation concomitant with an induction of cell death. We previously demonstrated that pharmaceutical-grade heparin inhibited virus-induced cell death with minor effects on in vitro virus replication in ZIKV-infected hNPCs. Here we show that heparin prevented ZIKV-induced intracellular vacuoles, a signature characteristic of paraptosis, but also inhibited necrosis and apoptosis of hNPCs when grown as neurospheres (NS). Furthermore, heparin preserved the differentiation of both ZIKV-infected human-induced pluripotent stem cells (hiPSC) derived-NPCs and fetus-derived NPCs into neural-glial cells. Collectively, these results highlight the potential neuroprotective effect of heparin that could be re-purposed and exploited to drive the development of novel agents for preventing ZIKV damage.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization 93%
- Replication of SARS-CoV-2 in human respiratory epithelium 93%
- Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response 93%
Similar papers in this journal
- Saxitoxin potentiates Zika virus-induced cell death in human neurons but not in neural progenitors and astrocytes 95%
- Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage 95%
- Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts 94%
Similar papers in this journal
- Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition 93%
- BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection 93%
- Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling 93%
Similar papers in this journal
- Intracellular Lipid Droplet Accumulation Occurs Early Following Viral Infection and Is Required for an Efficient Interferon Response 93%
- Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem 93%
- Targeting the latent human cytomegalovirus reservoir with virus specific nanobodies 93%
Similar papers in this journal
- A novel human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion 93%
- Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE 92%
- SARS-CoV-2 induces human endogenous retrovirus type W envelope protein expression in blood lymphocytes and in tissues of COVID-19 patients 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.