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Entropy Regularized Deconvolution of Cellular Cryo-Transmission Electron Tomograms

Croxford, M.; Elbaum, M.; Arigovindan, M.; Kam, Z.; Agard, D. A.; Villa, E.; Sedat, J.

2021-04-26 biophysics
10.1101/2021.04.26.441469 bioRxiv
Show abstract

Cryo-electron tomography (cryo-ET) allows for the high resolution visualization of biological macromolecules. However, the technique is limited by a low signal-to-noise ratio (SNR) and variance in contrast at different frequencies, as well as reduced Z resolution. Here, we applied entropy regularized deconvolution (ER DC) to cryo-electron tomography data generated from transmission electron microscopy (TEM) and reconstructed using weighted back projection (WBP). We applied DC to several in situ cryo-ET data sets, and assess the results by Fourier analysis and subtomogram analysis (STA).

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