Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis
Tourniere, O.; Busengdal, H.; Gahan, J. M.; Rentzsch, F.
Show abstract
Neurons are highly specialized cells present in nearly all animals, but their evolutionary origin and relationship to other cell types is not well understood. We use here the sea anemone Nematostella vectensis as a model system for early-branching animals to gain fresh insights into the evolutionary history of neurons. We generated a transgenic reporter line to show that the transcription factor NvInsm1 is expressed in post-mitotic cells that give rise to various types of neurons and secretory cells. Expression analyses, double transgenics and gene knockdown experiments show that the NvInsm1-expressing neurons and secretory cells derive from a common pool of NvSoxB(2)-positive progenitor cells. These findings, together with the requirement for Insm1 for the development of neurons and endocrine cells in vertebrates, support a close evolutionary relationship of neurons and secretory cells.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Hedgehog signaling is required for endomesodermal patterning and germ cell development in Nematostella vectensis 98%
- A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian 97%
- Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator 97%
Similar papers in this journal
- A Molecular, Spatial, and Regulatory Atlas of the Hydra vulgaris Nervous System 97%
- Shaking hands is a putative terminal selector and controls axon outgrowth of central complex neurons in the insect model Tribolium 96%
- A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination 96%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Prepontine non-giant neurons drive flexible escape behavior in zebrafish 96%
- DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling 96%
- Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.