Bacterial small RNAs and host epigenetic effectors of a transgenerational memory of pathogens in C. elegans.
Legüe, M. E.; Aguila, B.; Pollak, B.; Calixto, A.
Show abstract
The inheritance of memories is adaptive for survival. Microbes interact with all organisms challenging their immunity and triggering behavioral adaptations. Some of these behaviors induced by bacteria can be inherited although the mechanisms of action are largely unexplored. In this work, we use C. elegans and its bacteria to study the transgenerational RNA dynamics of an interspecies crosstalk leading to a heritable behavior. Heritable responses to bacterial pathogens in the nematode include avoidance and pathogen-induced diapause (PIDF), a state of suspended animation to evade the pathogen threat. We identify a small RNA RsmY, involved in quorum sensing from P. aeruginosa as required for initiation of PIDF. Histone methyltransferase SET-18/SMYD3 is also needed for PIDF initiation in C. elegans. In contrast, SET-25/EHMT2 is necessary for the maintenance of the memory of pathogen exposure in the transgenerational lineage. This work can be a starting point to understanding microbiome-induced inheritance of acquired traits.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans 95%
- Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways 94%
- SUMOylation of Jun fine-tunes the Drosophila gut immune response 94%
Similar papers in this journal
- The Gfr uptake system provides a context-dependent fitness advantage to Salmonella Typhimurium SL1344 during the initial gut colonization phase 94%
- Roles of RodZ and Class A PBP1b in the Assembly and Regulation of the Peripheral Peptidoglycan Elongasome in Ovoid-Shaped Cells of Streptococcus pneumoniae D39 93%
- High-throughput transposon sequencing highlights the cell wall as an important barrier for osmotic stress in methicillin resistant Staphylococcus aureus and underlines a tailored response to different osmotic stressors 93%
Similar papers in this journal
- Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. 96%
- DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence 95%
- Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster 94%
Similar papers in this journal
- Microbial colonization induces histone acetylation critical for inherited gut-germline-neural signaling 95%
- DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling 94%
- Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.