Abi3 regulates microglial ramification and dynamic tissue surveillance in vivo.
Simonazzi, E.; Jones, R.; Chen, F.; Ranson, A.; Stevenson-Hoare, J.; Escott-Price, V.; Sengpiel, F.; Morgan, B. P.; Taylor, P. R.
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A rare coding variant of Abelson-interactor gene family member 3 (Abi3) is associated with increased risk of late-onset Alzheimers Disease (AD). Although Abi3 is recognised as a core microglial gene, its role in microglia is largely unknown. Here we demonstrate that Abi3 is crucial for normal microglial morphology, distribution, and homeostatic tissue surveillance activity in vivo.
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