An fMRI-based brain marker predicts individual differences in delay discounting
Koban, L.; Lee, S.; Schelski, D. S.; Simon, M.-C.; Lerman, C.; Weber, B.; Kable, J. W.; Plassmann, H.
Show abstract
Individual differences in impatience--how much we discount future compared to immediate rewards--are associated with general life outcomes and related to substance use, psychiatric diseases, and obesity. Here, we use machine-learning on fMRI activity during an intertemporal choice task to develop a brain marker of individual differences in delay discounting. Study 1 (N=110) was used as a training and cross-validation set, resulting in significant prediction accuracy (r = 0.49) and suggesting an interplay between brain regions associated with affect, value, and cognitive control. The validity of the brain marker was replicated in an independent data set (Study 2, N=145, r = 0.45). In both studies, responses of the marker significantly differed between overweight and lean individuals. This pattern is a first step towards a generalizable neuromarker of delay discounting and a potentially transdiagnostic phenotype, which can be used as a brain-based target measure in future studies.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Value, confidence, deliberation: a functional partition of the medial prefrontal cortex demonstrated across rating and choice tasks 97%
- Social risk coding by amygdala activity and connectivity with dorsal anterior cingulate cortex 97%
- Dorsal Anterior Cingulate Cortex Encodes the Integrated Incentive Motivational Value of Cognitive Task Performance 97%
Similar papers in this journal
- Distinct neural contributions to metacognition for detecting (but not discriminating) visual stimuli 96%
- Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity 95%
- Opioid antagonism reduces wanting by strengthening frontostriatal connectivity 95%
Similar papers in this journal
- Neural Mechanisms of Feedback Processing and Regulation Recalibration during Neurofeedback Training 96%
- Network and State Specificity in Connectivity-Based Predictions of Individual Behavior 95%
- Tensorial Independent Component Analysis Reveals Social and Reward Networks Associated with Major Depressive Disorder 95%
Similar papers in this journal
- Grid-like entorhinal representation of an abstract value space during prospective decision making 96%
- Dynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex. 96%
- Tuned to Learn: An anticipatory hippocampal convergence state conducive to memory formation revealed during midbrain activation 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.