Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials
Rose, S. M.; Schmit, V. L.; Darton, T. C.; Eyal, N.; Magalhaes, M.; Morrison, J.; Peeler, M.; Shah, S. K.; Marsh, A. A.
Show abstract
In human challenge trials, volunteers are deliberately infected with a pathogen to accelerate vaccine development and answer key scientific questions. In the U.S., preparations for challenge trials with the novel coronavirus are complete, and in the U.K., challenge trials have recently begun. However, ethical concerns have been raised about the potential for invalid consent or exploitation. These concerns largely reflect worries that challenge trial volunteers may be unusually risk-seeking or too economically vulnerable to refuse the payments these trials provide, rather than being motivated primarily by altruistic goals. We conducted the first large-scale survey of intended human challenge trial volunteers and found that SARS-CoV-2 challenge trial volunteers exhibit high levels of altruistic motivations without any special indication of poor risk perception or economic vulnerability. Findings indicate that challenge trials with the novel coronavirus can attract volunteers with background conditions, attitudes, and motivations that should allay key ethical concerns.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The Role of Testing Availability on Intentions to Isolate during the COVID-19 Pandemic: A Randomized Trial 93%
- Integrating Operant and Cognitive Behavioral Economics to Inform Infectious Disease Response: Prevention, Testing, and Vaccination in the COVID-19 Pandemic 93%
- Gender-affirming care, mental health, and economic stability in the time of COVID-19: a global cross-sectional study of transgender and non-binary people 92%
Similar papers in this journal
- Patients Recovering from COVID-19 who Presented Anosmia During their Acute Episode have Behavioral, Functional, and Structural Brain Alterations 92%
- Psychological factors underpinning vaccine willingness in Israel, Japan and Hungary 91%
- Age- and gender-dependent differences in attitudes towards COVID-19 vaccination and underlying psychological processes 91%
Similar papers in this journal
- Perceived vulnerability to COVID-19 infection from event attendance: Results from Louisiana, USA, two weeks preceding the national emergency declaration 92%
- Homebound by COVID19: The Benefits and Consequences of Non-Pharmaceutical Intervention Strategies 92%
- COVID-19 vaccine hesitancy in the UK: A longitudinal household cross-sectional study 91%
Similar papers in this journal
- Cohort Profile: A national prospective cohort study of SARS-CoV-2 pandemic outcomes in the U.S. - The CHASING COVID Cohort Study 93%
- Predictors of COVID-19 vaccine acceptance across time and countries 92%
- COVID-19 risk perceptions of social interaction and essential activities and inequity in the United States: Results from a nationally representative survey 92%
Similar papers in this journal
- Addressing cultural and knowledge barriers to enable preclinical sex inclusive research 93%
- The Effect of COVID-19 on the Postdoctoral Experience: a comparison of pre-pandemic and pandemic surveys. 92%
- Effects of Side-Effect Risk Framing Strategies on COVID-19 Vaccine Intentions: A Randomized Controlled Trial 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.