Durability of SARS-CoV-2-specific IgG responses in saliva for up to 8 months after infection
Randad, P. R.; Pisanic, N.; Kruczynski, K.; Howard, T.; Gregory Rivera, M.; Spicer, K.; Antar, A. A. R.; Penson, T.; Thomas, D. L.; Pekosz, A.; Ndahiro, N.; Aliyu, L.; Betenbaugh, M. J.; Manley, H.; Detrick, B.; Katz, M.; Cosgrove, S.; Rock, C.; Zyskind, I.; Silverberg, J. I.; Rosenberg, A. Z.; Duggal, P.; Manabe, Y. C.; Collins, M. H.; Heaney, C. D.
Show abstract
We evaluated the durability of IgG responses specific to SARS-CoV-2 nucleocapsid (N), receptor binding domain (RBD), and spike (S) antigens in saliva up to 8 months after RT-PCR-confirmed COVID-19 using a multiplex salivary assay. We estimated a half-life of 64 days (d) (95% CI: 49, 80 d) for N, 100 d for RBD (95% CI: 58, 141 d), and 148 d (95% CI: 62, 238 d) for S IgG responses in saliva, consistent with half-life estimates previously reported in blood. Saliva can serve as an alternative to blood to monitor humoral immune responses on a large scale following SARS-CoV-2 infection and vaccination for surveillance and assessment of population immunity.
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