Detection of the germline specific NAC protein paralog enriched by intrinsically disordered regions in Drosophila melanogaster
Kogan, G. L.; Mikhaleva, E. A.; Olenkina, O. M.; Ryazansky, S. S.; Galzitskaya, O. V.; Abramov, Y. A.; Leinsoo, T. A.; Akulenko, N. V.; Gvozdev, V. A.
Show abstract
Nascent polypeptide associated complex (NAC) consisting of - and {beta}-subunits is an essential conserved ubiquitously expressed ribosome-associated protein in eukaryotes. NAC is considered as a chaperone and co-translational regulator of nascent protein sorting providing homeostasis of cellular proteins. Here we discovered the germinal cell specific NAC (gNAC) homologue, which differs from the ubiquitously expressed NAC by the presence of expanded intrinsically disordered regions (IDRs) at the N- and C-ends of the - and {beta}-subunits, respectively. We propose these evolutionary acquisition of long IDRs drive gNAC to endow both the specific conformational plasticity for binding client proteins and novel functions regulated by post-transcriptional modifications (PTM). At the same time, we demonstrated that the well-known lethal effect of the loss of ubiquitous NAC-{beta} is suppressed by ectopic expression of its germinal paralog indicating the absence of strict functional differences between the ubiquitous and germline NAC-{beta} subunit paralogs for protein homeostasis.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Cold-sensing TRP channels and temperature preference modulate ovarian development in the model organism Drosophila melanogaster 94%
- Cracking the floral quartet code: How do multimers of MIKC C-type MADS-domain transcription factors recognize their target genes? 92%
- Analysis of the Toll and spaetzle genes involved in Toll path-way-dependent antimicrobial gene induction in the red flour beetle, Tribolium castaneum (Coleoptera: Tenebriodae) 92%
Similar papers in this journal
- The male mouse meiotic cilium emanates from the mother centriole at zygotene prior to centrosome duplication 93%
- Enhanced loss of retinoic acid network genes in Xenopus laevis achieves a tighter signal regulation 93%
- A trans-omics comparison reveals common gene expression strategies in four model organisms and exposes similarities and differences between them 93%
Similar papers in this journal
- Drosophila architectural protein CTCF is not essential for fly survival and is able to function independently of CP190 94%
- Inferring biosynthetic and gene regulatory networks from Artemisia annua RNA sequencing data on a credit card-sized ARM computer 92%
- siRNA enrichment in Argonaute 2-depleted Blattella germanica 91%
Similar papers in this journal
- The seminal vesicle is a juvenile hormone-responsive tissue in adult male Drosophila melanogaster 96%
- Evolutionary analysis of p38 stress-activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress 96%
- Pigment-Dispersing Factor is present in circadian clock neurons of pea aphids and may mediate photoperiodic signaling to insulin-producing cells 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.