Differential effects on neuromuscular physiology between Sod loss-of-function mutation and paraquat-induced oxidative stress in Drosophila
Ueda, A.; Iyengar, A.; Wu, C.-F.
Show abstract
Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of Superoxide dismutase (Sod) and by paraquat (PQ) feeding in Drosophila. We demonstrated alterations in Sod mutants; the larval neuromuscular junction displayed supernumerary discharges and the adult giant-fiber escape pathway showed increased latency and poor response to repetitive high-frequency stimulation. Even though the concentrations used led to motor coordination defects and lethality, PQ feeding failed to reproduce such performance deficits in these larval and adult preparations, indicating mechanistic distinctions between genetic and pharmacological manipulation of oxidative stress.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Behavior choices amongst grooming, feeding, and courting in Drosophila show contextual flexibility, not an absolute hierarchy of needs 95%
- Directional invariance in the Drosophila giant fiber escape circuit 94%
- FreeClimber: Automated quantification of climbing performance in Drosophila, with examples from mitonuclear genotypes 94%
Similar papers in this journal
- Homeostatic depression shows heightened sensitivity to synaptic calcium 94%
- NADPH oxidase generated reactive oxygen species and aquaporin conduits mediate activity-regulated dendritic plasticity. 94%
- Trophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells. 92%
Similar papers in this journal
Similar papers in this journal
- Dopamine signaling in wake promoting clock neurons is not required for the normal regulation of sleep in Drosophila 95%
- Changes in presynaptic gene expression during homeostatic compensation at a central synapse 94%
- Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.