Mito-nuclear variation in transgenerational and reproductive effects of amino acid and lipid nutrition
Dobson, A.; Kumpitsch, L.; Langer, L.; Voigt, E.; Dowling, D. K.; Reinhardt, K.
Show abstract
Epistasis between mitochondrial and nuclear genomes can modulate fitness effects of nutrition. Are these "mitonuclear" effects deterministic with regard to optimal nutrition? Which nutrients and genetic loci participate? Here, in fruitflies, we show that mitonuclear epistasis repeatably dictates fitness effects of dietary lipids and amino acids, with a tripartite interaction emerging as an unprecedented source of quantitative variation. We also observed diet-dependent developmental lethality and parental effects, but only in specific mitonucleotypes. Associating phenotype to mtDNA variation implicated a non-coding RNA (mt:lrRNA), suggesting a novel mechanism, with epistasis between mitochondria-derived regulatory factors and the nuclear genome producing qualitative differences in how diet impacts fitness. SUMMARYCombined action of nuclear genotype and regulatory loci on mtDNA produces major differences in fitness impacts of nutrition.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Endosymbiont hijacking of acylcarnitines regulates insect vector fecundity by suppressing the viability of stored sperm 94%
- Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models 93%
- Patterns of recent natural selection on genetic loci associated with sexually differentiated human body size and shape phenotypes 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.