Loss of FAS1 function reveals rescue of an aberrant intra-S-phase checkpoint by the G2/M checkpoint regulator SOG1
Eekhout, T.; Dvorackova, M.; Pedroza Garcia, J.; Nespor Dadejova, M.; Kalhorzadeh, P.; Van den Daele, H.; Vercauteren, I.; Fajkus, J.; De Veylder, L.
Show abstract
The WEE1 and ATR kinases represent important regulators of the plant intra-S-phase checkpoint, as evidenced by the hypersensitivity of WEE1KO and ATRKO roots to replication inhibitory drugs. Here, we report on the identification of a defective allele of the FASCIATA1 (FAS1) subunit of the chromatin assembly factor 1 (CAF-1) complex as a suppressor of WEE1- or ATR-deficient plants. We demonstrate that lack of FAS1 activity results in the activation of an ATM- and SOG1-mediated G2/M-arrest that makes the ATR and WEE1 checkpoint regulators redundant. This ATM activation accounts for telomere erosion and loss of ribosomal DNA described for the fas1 plants. Knocking out SOG1 in the fas1 wee1 background restores replication stress sensitivity, demonstrating that SOG1 plays a prominent role as secondary checkpoint regulator in plants that fail to activate the intra-S-phase checkpoint. One-Sentence SummaryLack of the chromatin assembly factor-1 subunit FAS1 results in a DNA damage response that overrules the need for replication checkpoint activators.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The Role of SIAMESE in G2 Checkpoint Regulation in Arabidopsis thaliana 96%
- miR156-independent repression of the ageing pathway bylongevity-promoting AHL proteins in Arabidopsis 96%
- ETHYLENE RESPONSE FACTOR 115 integrates jasmonate and cytokinin signaling machineries to repress adventitious rooting in Arabidopsis 96%
Similar papers in this journal
- Jasmonate inhibits adventitious root initiation through transcriptional repression of CKX1 and activation of RAP2.6L transcription factor in Arabidopsis 96%
- MYB12 spatiotemporally represses TMO5/LHW-mediated transcription in the Arabidopsis root meristem 96%
- IBA endogenous auxin regulates Arabidopsis root system development in a glutathione-dependent way and is important for adaptation to phosphate deprivation. 96%
Similar papers in this journal
- Downy mildew effector HaRxL106 interacts with the transcription factor BIM1 altering plant growth, BR signaling and susceptibility to pathogens 96%
- A complex tissue-specific interplay between the Arabidopsis transcription factors AtMYB68, AtHB23, and AtPHL1 modulates primary and lateral root development and adaptation to salinity 96%
- DEFECTIVELY ORGANIZED TRIBUTARIES 5 is not required for leaf venation patterning in Arabidopsis thaliana 96%
Similar papers in this journal
- The unequal functional redundancy of Arabidopsis INCURVATA11 and CUPULIFORMIS2 is not dependent on genetic background 97%
- OsbZIP47 an integrator for meristem regulators during rice plant growth and development 96%
- Maize (Zea mays L.) nucleoskeletal proteins regulate nuclear envelope remodeling and function in stomatal complex development and pollen viability. 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.