The association of CREBRF variant rs373863828 with body composition in adult Samoans
Nicola L. Hawley; Rachel L. Duckham; Jenna C. Carlson; Take Naseri; Muagututia Sefuiva Reupena; Viali Lameko; Alysa Pomer; Abigail Wetzel; Melania Selu; Vaimoana Lupematisila; Folla Unasa; Lupesina Vesi; Tracy Fatu; Seipepa Unasa; Kima Faasalele-Savusa; Satupaitea Viali; Anna C. Rivara; Emily M. Russell; Ranjan Deka; Erin E. Kershaw; Ryan L. Minster; Daniel E. Weeks; Stephen T. McGarvey
Show abstract
Objective: The minor allele of rs373863828, a missense variant in CREBRF, is associated with higher BMI but lower odds of type 2 diabetes in Pacific Islanders. Methods: To test if this protective effect operates through metabolically favorable body fat distribution, we examined the association of the minor A allele with body composition, measured using dual-energy x-ray absorptiometry (DXA), in a cross-sectional study of n=421 Samoan adults. Results: We replicated our earlier finding that this allele was associated with higher weight and BMI, although it was statistically significant only in women. There was no significant association of genotype with percent body fat, visceral adiposity or fat distribution, although in women, the A allele was associated with greater total fat mass (p=0.02), android (p=0.009) and trunk fat (p=0.01). In both sexes, age- and height-adjusted average lean mass was significantly greater per copy of the A allele: 2.16 kg/copy in women and 1.73 kg/copy in men. Conclusions: These data do not support a primary role of fat distribution in mediating the association between rs373863828 genotype and type 2 diabetes risk. We suggest an alternative hypothesis: those with the A allele may more efficiently regulate blood glucose because of their greater absolute lean mass.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- G-Protein Coupled Receptor 19 (Gpr19) Knockout Mice Display Sex-Dependent Metabolic Dysfunction 93%
- Identification of metabolomics biomarkers for type 2 diabetes: triangulating evidence from longitudinal and Mendelian randomization analyses 92%
- Genome-wide Polygenic Risk Score for Type 2 Diabetes in Indian Population 92%
Similar papers in this journal
- Interscapular fat is associated with impaired glucose tolerance and insulin resistance independent of visceral fat mass 93%
- MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease 92%
- Genome wide association study in 3,173 outbred rats identifies multiple loci for body weight, adiposity, and fasting glucose 92%
Similar papers in this journal
- The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry 97%
- Birth weight, BMI in adulthood and latent autoimmune diabetes in adults: A Mendelian randomization study 94%
- Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response 93%
Similar papers in this journal
- Increased adipose tissue indices of androgen catabolism and aromatization in women with metabolic dysfunction 94%
- Circulating metabolic biomarkers are consistently associated with incident type 2 diabetes in Asian and European populations – a metabolomics analysis in five prospective cohorts 93%
- Impaired Suppression of Plasma Lipid Extraction and its Partitioning Away from Muscle by Insulin in Humans with Obesity 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.