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Succinate is Broadly Tissue-Permeant and Uncouples Mitochondrial Respiration from ATP Synthesis

Hass, D. T.; Robbings, B. M.; Bisbach, C. M.; Giering, E.; Mundinger, T. O.; Sadilek, M.; Sweet, I. R.; Hurley, J. B.

2021-02-10 biochemistry
10.1101/2021.02.10.430650 bioRxiv
Show abstract

Succinate is central in energy metabolism. It is thought to be made and consumed within mitochondria, and not to cross the plasma membrane. Contrary to the canonical role of succinate, it is produced in the retina and released into the extracellular milleau. It is unknown how this affects adjacent retinal pigment epithelium, within eyecup tissue. By measuring consumption of 13C4-succinate and O2 we probe metabolism of the eyecup, we find robust succinate consumption by eyecup but not retina tissue. Succinate-dependant stimulation of eyecup respiration is oligomycin resistant; indicating that in eyecup tissue succinate uncouples mitochondrial ATP synthesis from respiration.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.