Expansion of cortical layers 2 and 3 in human left temporal cortex associates with verbal intelligence
Heyer, D. B.; Wilbers, R.; Galakhova, A. A.; Hartsema, E.; Braak, S.; Hunt, S.; Verhoog, M. B.; Muijtjens, M. L.; Mertens, E. J.; Idema, S.; Baayen, J. C.; de Witt Hamer, P. C.; Klein, M.; McGraw, M.; Lein, E. S.; de Kock, C. P. J.; Mansvelder, H. D.; Goriounova, N. A.
Show abstract
The expansion of supragranular cortical layers is thought to have enabled evolutionary development of human cognition and language. However, whether increased volume of supragranular cortical layers can actually support greater cognitive and language abilities in humans has not been demonstrated. Here, we find that subjects with higher general and verbal intelligence test (VIQ) scores have selectively expanded layers 2 and 3 only in the left temporal cortex, an area associated with language and IQ-test performance. This expansion is accompanied by lower neuron densities and larger cell-body size. Furthermore, individuals with higher VIQ scores had neurons with larger dendritic trees in left temporal cortex, potentially impacting their function. Indeed, neurons of subjects with higher VIQ scores had faster action potential upstroke kinetics, which improves information processing. These data show that expansion of supragranular layer volume, cortical and cellular micro-architecture and function are associated with improved verbal mental ability in human subjects.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Aberrant axonal pathfinding and exuberant myelination in an inducible model of neocortical heterotopia 95%
- Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area 95%
- Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components 94%
Similar papers in this journal
- HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species 96%
- The reliability and heritability of cortical folds and their genetic correlations across hemispheres. 96%
- Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees 95%
Similar papers in this journal
- Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy 96%
- Beyond the Resection: Surgical White Matter Disruption alters Non-Resected Brain Anatomy 95%
- Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.