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Golden hamster piRNAs are necessary for early embryonic development and establishment of spermatogonia

Loubalova, Z.; Fulka, H.; Horvat, F.; Pasulka, J.; Malik, R.; Hirose, M.; Ogura, A.; Svoboda, P.

2021-01-28 molecular biology
10.1101/2021.01.27.428513 bioRxiv
Show abstract

PIWI-associated RNAs (piRNAs) support the germline by suppressing retrotransposons and genes. In mice, piRNAs are essential for spermatogenesis but not oogenesis. To test how this applies to other mammals, we deleted Mov10l1 helicase in golden hamster, whose piRNA pathway is configured more similarly to that of other mammals. Mov10l1-/- male hamsters showed impaired establishment of spermatogonia accompanied by transcriptome dysregulation and a surge in MYSERV retrotransposon expression. The rare viable spermatogenic cells showed a meiotic failure phenotype like Mov10l1-/- mice. Female Mov10l1-/- hamsters were sterile due to post-meiotic loss of developmental competence in zygotes. Unique phenotypes of Mov10l1-/- hamsters demonstrate the adaptive nature of piRNA-mediated control of genes and retrotransposons in order to confront emerging genomic threats or acquire new physiological roles.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.