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The urea cycle is transcriptionally controlled by hypoxia-inducible factors
Singh, C.; Benos, A.; Grenell, A.; Tran, V.; Hanna, D.; Kannekanti, N.; Anand-Apte, B.; Brunengraber, H.; Sears, J.
2021-01-27
biochemistry
10.1101/2021.01.25.428152
bioRxiv
Show abstract
Here, we demonstrate transcriptional regulation of urea cycle genes CPS1 and ARG1 by hypoxia-inducible factors (HIFs) and demonstrate a hepatic HIF dependent increase in urea cycle activity.
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