Small peptides modulate the immune function of the ion channel-like protein ACD6 in Arabidopsis thaliana
Zhu, W.; Li, L.; Neuhaeuser, B.; Thelen, M.; Wang, M.; Chen, J.; Wei, L.; Venkataramani, K.; Exposito-Alonso, M.; Liu, C.; Keck, J.; Barragan, A. C.; Schwab, R.; Lutz, U.; Ludewig, U.; Weigel, D.
Show abstract
ACCELERATED CELL DEATH 6 (ACD6) mediates a trade-off between growth and defense in Arabidopsis thaliana. However, the precise biochemical mechanism by which ACD6 and related proteins in plants act remains enigmatic. Here, we identified two loci, MODULATOR OF HYPERACTIVE ACD6 1 (MHA1) and its paralog MHA1-LIKE (MHA1L), that code for [~]7 kDa proteins that differentially interact with specific ACD6 variants. MHA1L enhances accumulation of an ACD6 complex, thereby increasing activity of the ACD6 standard allele for regulating plant growth and defenses. ACD6 is a multipass transmembrane protein with intracellular ankyrin repeats that are structurally similar to those found in mammalian ion channels. Several lines of evidence link increased ACD6 activity to enhanced calcium influx, likely mediated by ACD6 itself and with MHA1L as a direct regulator of ACD6.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity 97%
- Humidity-driven ABA depletion determines plant-pathogen competition for leaf water 97%
- Fertilization-induced synergid cell death by RALF12-triggered ROS production and ethylene signaling 97%
Similar papers in this journal
Similar papers in this journal
- Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition 95%
- Expression of a CO2-permeable aquaporin enhances mesophyll conductance in the C4 species Setaria viridis 95%
- Interdependence of plasma membrane nanoscale dynamics of a kinase and its cognate substrate underlies Arabidopsis response to viral infection 95%
Similar papers in this journal
- S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs 97%
- PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana 97%
- An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth 97%
Similar papers in this journal
- ABA homeostasis and long-distance translocation is redundantly regulated by ABCG ABA importers 97%
- Two interacting transcriptional coactivators cooperatively control plant immune responses 97%
- Substrate specificity and protein stability drive the divergence of plant-specific DNA methyltransferases 97%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.