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Fiber photometry does not reflect spiking activity in the striatum

Legaria, A. A.; Licholai, J. A.; Kravitz, A.

2021-01-21 neuroscience
10.1101/2021.01.20.427525 bioRxiv
Show abstract

Calcium recording via fiber photometry is commonly used as a proxy for recording population neuronal activity in vivo, yet the biological source of the photometry signal remains unclear. Here, using simultaneous in vivo extracellular electrophysiology and fiber photometry in the striatum, along with endoscopic 1-photon and 2-photon calcium imaging, we determined that the striatal fiber photometry signal reflects primarily non-somatic, and not somatic, changes in calcium.

Published in Nature Neuroscience (predicted rank #2) · training set

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