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Apolipoprotein E genotype and MRI-detected brain alterations pertaining to neurodegeneration: A systematic review

2021-01-22 radiology and imaging Title + abstract only
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IntroductionThe effect of apolipoprotein E (APOE) genotype, particularly APOE {varepsilon}4, the main genetic risk factor for late-onset Alzheimers disease (LOAD), has been widely explored in neuroimaging studies pertaining to older adults. The goal of this systematic review was to review the literature on the relationship between carriage of the APOE {varepsilon}4 allele and grey matter (GM) changes across various age groups and its influence on neurodegeneration as evidenced by structural magn...

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