A conserved regulatory module regulates receptor kinase signaling in immunity and development
DeFalco, T. A.; Anne, P.; James, S. R.; Willoughby, A.; Johanndrees, O.; Genolet, Y.; Pullen, A.-M.; zipfel, c.; Hardtke, C.; Nimchuk, Z. L.
Show abstract
Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signaling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signaling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development employ a similar regulatory module. In the absence of ligand, signaling is dampened through association with specific type-2C protein phosphatases (PP2Cs). Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting their release from the receptor complexes. Our work reveals a regulatory circuit shared between immune and developmental receptor signaling, which may have broader important implications for plant receptor kinase-mediated signaling in general.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Constitutive activation of leucine-rich repeat receptor kinase signaling pathways by BAK1-interacting receptor-like kinase 3 chimera 98%
- Ectopic assembly of an auxin efflux control machinery shifts developmental trajectories 97%
- TOR coordinates nucleotide availability with ribosome biogenesis in plants 97%
Similar papers in this journal
- An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species 97%
- Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface 96%
- Acetylation of a fungal effector that translocates host PR1 facilitates virulence 96%
Similar papers in this journal
- The Ralstonia solanacearum effector RipAV targets Plant U-box proteins and induces proteasomal-dependent degradation of BIK1 96%
- ETHYLENE RESPONSE FACTOR 115 integrates jasmonate and cytokinin signaling machineries to repress adventitious rooting in Arabidopsis 96%
- A conserved gene regulatory network controls root epidermal cell patterning in superrosid species 96%
Similar papers in this journal
Similar papers in this journal
- Direct acetylation of the conserved threonine of an immune regulator by bacterial effectors activates RPM1-dependent immunity in Arabidopsis 97%
- A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease 96%
- DET1-mediated COP1 regulation avoids HY5 activity over second-site targets to tune plant photomorphogenesis 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.