SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients
Rosin, N. L.; Jaffer, A.; Sinha, S.; Mulloy, R. P.; Robinson, C.; Labit, E.; Almeida, L. G.; Dufour, A.; Corcoran, J. A.; Yipp, B.; Biernaskie, J.
Show abstract
In late 2019 a novel coronavirus (SARS-CoV-2) emerged, and has since caused a global pandemic. Understanding the pathogenesis of COVID-19 disease is necessary to inform development of therapeutics, and management of infected patients. Using scRNAseq of blood drawn from SARS-CoV-2 patients, we asked whether SARS-CoV-2 may exploit immune cells as a Trojan Horse to disseminate and access multiple organ systems. Our data suggests that circulating cells are not actively infected with SARS-CoV-2, and do not appear to be a source of viral dissemination.
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