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A sexual dimorphic role of the miR-465 cluster in placental development

Wang, Z.; Meng, N.; Wang, Y.; Zhou, T.; Li, M.; Wang, S.; Chen, S.; Zheng, H.; Kong, S.; Wang, H.; Yan, W.

2021-01-17 developmental biology
10.1101/2021.01.16.426973 bioRxiv
Show abstract

A sexually dimorphic role of miRNAs in placental development has never been reported. Here, we show that ablation of the miR-465 cluster caused selective degeneration of female conceptuses as early as embryonic day (E)8.5, leading to a male-biased sex ratio (60% males) among miR-465 KO mice. Given that the miR-465 cluster miRNAs were predominantly expressed in the extraembryonic tissue and ablation of these miRNAs led to dysregulation of numerous critical placental genes, our data strongly suggest the miR-465 cluster is required for full developmental potential of the female, but not the male, extraembryonic tissue/placenta.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.