Impacts of 203/204: RG>KR mutation in the N protein of SARS-CoV-2
Vahed, M.; Calcagno, T. M.; Quinonez, E.; Mirsaeidi, M.
Show abstract
We present a structure-based model of phosphorylation-dependent binding and sequestration of SARS-CoV-2 nucleocapsid protein and the impact of two consecutive amino acid changes R203K and G204R. Additionally, we studied how mutant strains affect HLA-specific antigen presentation and correlated these findings with HLA allelic population frequencies. We discovered RG>KR mutated SARS-CoV-2 expands the ability for differential expression of the N protein epitope on Major Histocompatibility Complexes (MHC) of varying Human Leukocyte Antigen (HLA) origin. The N protein LKR region K203, R204 of wild type (SARS-CoVs) and (SARS-CoV-2) observed HLA-A*30:01 and HLA-A*30:21, but mutant SARS-CoV-2 observed HLA-A*31:01 and HLA-A*68:01. Expression of HLA-A genotypes associated with the mutant strain occurred more frequently in all populations studied. ImportanceThe novel coronavirus known as SARS-CoV-2 causes a disease renowned as 2019-nCoV (or COVID-19). HLA allele frequencies worldwide could positively correlate with the severity of coronavirus cases and a high number of deaths.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention 97%
- SARS-CoV-2: Proof of recombination between strains and emergence of possibly more virulent ones 97%
- Design of multi-epitope vaccine candidate against Brucella type IV secretion system (T4SS) 96%
Similar papers in this journal
- SARS-CoV-2 mutations and where to find them: An in silico perspective of structural changes and antigenicity of the Spike protein 97%
- Computationally validated SARS-CoV-2 CTL and HTL Multi-Patch Vaccines designed by reverse epitomics approach, shows potential to cover large ethnically distributed human population worldwide 96%
- Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern 96%
Similar papers in this journal
- SARS-CoV-2-induced humoral immunity through B cell epitope analysis and neutralizing activity in COVID-19 infected individuals in Japan 95%
- Emergence of SARS-CoV-2 Omicron Variant JN.1 in Tamil Nadu, India - Clinical Characteristics and Novel Mutations 95%
- Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity 94%
Similar papers in this journal
- Genome based Evolutionary study of SARS-CoV-2 towards the Prediction of Epitope Based Chimeric Vaccine 96%
- Understanding the B and T cells epitopes of spike protein of severe respiratory syndrome coronavirus-2: A computational way to predict the immunogens 96%
- Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission 96%
Similar papers in this journal
- Large-scale template-based structural modeling of T-cell receptors with known antigen specificity reveals complementarity features. 96%
- Immuno-informatics Study Identifies Conserved T Cell Epitopes in Non-structural Proteins of Bluetongue Virus Serotypes: Formulation of Computationally Optimized Next-Generation Broad-spectrum Multiepitope Vaccine 95%
- Association of HLA class I genotypes with age at death of COVID-19 patients 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.