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MiDAS - Meaningful Immunogenetic Data at Scale

Migdal, M.; Ruan, D. F.; Forrest, W. F.; Horowitz, A.; Hammer, C.

2021-01-14 bioinformatics
10.1101/2021.01.12.425276 bioRxiv
Show abstract

Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. We present MiDAS, an R package enabling statistical association analysis and using immunogenetic data transformation functions for HLA amino acid fine mapping, analysis of HLA evolutionary divergence as well as HLA-KIR interactions. MiDAS closes the gap between inference of immunogenetic variation and its efficient utilization to make meaningful discoveries.

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