Homology modeling and functional characterization of multidrug effluxor Mta protein from Bacillus Atrophaeus: An explanatory insilico approach
Rahman, M. R.; Chowdhury, I. M.; Banik, A.; Sajib, E. H.
Show abstract
Phenotypically similar to B. subtilis, Bacillus atrophaeus is a Gram-positive, aerobic, spore-forming bacteria. It is a black-pigmented bacterial genus. Therefore, it is of interest to study the uncharacterized proteins in the genome. For a detailed computational sequence-structure-function analysis using available data and resources, an uncharacterized protein Mta (AKL87074.1) in the genome was selected. In this study, attempts were made to study the physicochemical properties, predict secondary structure, modeling the 3-D protein, pocket identification, protein-protein interaction and phylogenetic analysis of Mta protein. The predicted active site using CASTp is analyzed for understanding their multidrug resistance function. Because Mta is a MerR family member, these investigations on these functional aspects could lead us for better understanding of antibiotic resistance phenomenon.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Ab initio modelling of an essential mammalian protein: Transcription Termination Factor 1 (TTF1) 96%
- Optimized structure of monoubiquitinated FANCD2 (human) at Lys 561: a theoretical approach 95%
- Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern 95%
Similar papers in this journal
- Heterologous expression and characterization of mutant cellulase from indigenous strain of Aspergillus niger 97%
- Comparative in silico analysis of ftsZ gene from different bacteria reveals the preference for core set of codons in coding sequence structuring and secondary structural elements determination 96%
- Metabolic engineering of Bacillus subtilis with an Endopolygalacturonase gene Isolated from Pectobacterium carotovorum; a Plant Pathogenic bacterial strain. 95%
Similar papers in this journal
- An Issue of Concern: Unique Truncated ORF8 Protein Variants of SARS-CoV-2 96%
- Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure 96%
- Structural, functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics. 93%
Similar papers in this journal
- Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India 95%
- Glibenclamide, ATP and Metformin Increases the Expression of Human Bile Salt Export Pump ABCB11 94%
- SNPector: SNP inspection tool for diagnosing gene pathogenicity and drug response in a naked sequence 93%
Similar papers in this journal
- In Silico Analysis Predicting Effects of Deleterious SNPs of Human RASSF5 Gene on its Structure and Functions 94%
- The Evolutionary History Of The Orexin/Allatotropin Gpcr Family: From Placozoa And Cnidaria To Vertebrata 93%
- Machine learning prediction of antiviral-HPV protein interactions for anti-HPV pharmacotherapy 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.