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Precision mapping of the mouse brain metabolome

Pang, H.; Li, J.-L.; Hu, X.-L.; Chen, F.; Gao, X.; Zacharias, L. G.; Cai, F.; DeBerardinis, R. J.; Sun, W.; Hu, Z.; Ge, W.-p.

2020-12-29 neuroscience
10.1101/2020.12.28.424544 bioRxiv
Show abstract

Metabolism is physiologically fundamental to a biological system. Understanding brain metabolism is critical for our comprehensive knowledge of brain function in health and disease. Combining a microarray collection system with targeted metabolomics analysis, here we performed precision mapping of the metabolome in the mouse brain and created maps for 79 metabolites with a resolution of 0.125mm3 per pixel (i.e., brain subregion). The metabolome atlas provides researchers with a useful resource to interpret the vulnerability of specific brain regions to various disease-relevant metabolic perturbations.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.