Molecular diversity analysis of the spike glycoprotein (S) gene from Hong Kong - China
Da Silva, E. D. A. B.; Venancio, D. B. R.; Albuquerque, R. M. d.; Ramos, R. d. S.; Felix, P. T.
Show abstract
In this work, 37 haplotypes of spike glycoprotein of SARS-CoV-2 from Hong Kong, China, were used. All sequences were publicly available on the Platform of the National Center for Biotechnology Information (NCBI) and were analyzed for their Molecular Variance (AMOVA), haplotypic diversity, mismatch, demographic and spatial expansion, molecular diversity and time of evolutionary divergence. The results suggested that there was a low diversity among haplotypes, with very low numbers of transitions, transversions, indels-type mutations and with total absence of population expansion perceived in the neutrality tests. The estimators used in this study supported the uniformity among all the results found and confirm the evolutionary conservation of the gene, as well as its protein product, a fact that stimulates the use of therapies based on neutralizing antibodies, such as vaccines based on protein S.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- SARS-CoV-2: Proof of recombination between strains and emergence of possibly more virulent ones 94%
- An in-silico study of the mutation-associated effects on the spike protein of SARS-CoV-2, Omicron variant 94%
- Treatment Profiles And Clinical Outcomes Of COVID-19 Patients At Private Hospital In Jakarta 94%
Similar papers in this journal
- Genome based Evolutionary study of SARS-CoV-2 towards the Prediction of Epitope Based Chimeric Vaccine 95%
- Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission 95%
- E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil 94%
Similar papers in this journal
- Mutational analysis and assessment of its impact on proteins of SARS-CoV-2 genomes from India 94%
- VEGF and FGF signaling during head regeneration in hydra 92%
- Improving the phylogenetic resolution of Malaysian and Javan mahseer (Cyprinidae), Tor tambroides and Tor tambra: Whole mitogenomes sequencing, phylogeny and potential mitogenome markers 91%
Similar papers in this journal
- Molecular features similarities between SARS-CoV-2, SARS, MERS and key human genes could favour the viral infections and trigger collateral effects 94%
- The Evolutionary History Of The Orexin/Allatotropin Gpcr Family: From Placozoa And Cnidaria To Vertebrata 93%
- Comprehensive bioinformatic analysis of newly sequenced Turdoides affinis mitogenome reveals the persistence of translational efficiency and dominance of NADH dehydrogenase complex-I in electron transport system over Leiothrichidae family 93%
Similar papers in this journal
- Genomic variations in SARS-CoV-2 genomes from Gujarat: Underlying role of variants in disease epidemiology 94%
- Deciphering inhibitory mechanism of coronavirus replication through host miRNAs-RNA-dependent RNA polymerase (RdRp) interactome 93%
- Whole-genome sequencing of Vero E6 (C1008) and comparative analysis of four Vero cell sublines 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.