RORα enforces stability of the T-helper-17 cell effector program
Lee, J.-Y.; Hall, J. A.; Pokrovskii, M.; Kroehling, L.; Wu, L.; Littman, D. R.
Show abstract
T helper 17 (Th17) cells regulate mucosal barrier defenses, but also promote multiple autoinflammatory diseases. Although many molecular determinants of Th17 cell differentiation have been described, the transcriptional programs that sustain Th17 cells in vivo remain obscure. The transcription factor ROR{gamma}t is critical for Th17 cell differentiation, but a distinct role of the closely-related ROR, which is co-expressed in Th17 cells, is not known. Here we demonstrate that, although dispensable for Th17 cell differentiation, ROR governs optimal Th17 responses in peripheral tissues. Thus, the absence of ROR in T cells led to significant reductions in both ROR{gamma}t expression and effector function amongst Th17 cells, due to need for cooperative ROR and ROR{gamma}t binding to a newly-identified Rorc enhancer element that is essential for Th17 lineage maintenance in vivo. Altogether, these data point to a non-redundant role of ROR in Th17 lineage maintenance via reinforcement of the ROR{gamma}t transcriptional program.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints 96%
- The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling 96%
- Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type-1 diabetes 96%
Similar papers in this journal
- BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen 96%
- T cell receptor is required for differentiation but not maintenance of intestinal intraepithelial lymphocytes 96%
- An Interleukin 9-Zbtb18 axis promotes germinal center development of memory B cells 95%
Similar papers in this journal
Similar papers in this journal
- Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages 97%
- Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity 97%
- CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells 96%
Similar papers in this journal
- Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity 95%
- Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program 95%
- A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.