Frequency matters: Up- and Down-Regulation of Dopamine Tone Induces Similar Frequency Shifts in Cortico-Basal Ganglia Beta Oscillations
Iskhakova, L.; Rappel, P.; Fonar, G.; Marmor, O.; Paz, R.; Israel, Z.; Eitan, R.; Bergman, H.
Show abstract
Beta oscillatory activity (13-30Hz) is pervasive within the cortico-basal ganglia (CBG) network. Studies in Parkinsons disease (PD) patients and animal models suggested that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine-tone remains unclear. We recorded neural activity in the CBG network of non-human-primates (NHP) while acutely up- and down-modulating dopamine levels. Further, we assessed changes in beta oscillations of PD patients following acute and chronic changes in dopamine-tone. Beta oscillation frequency was strongly coupled with dopamine-tone in both NHPs and human patients. In contrast, power, coherence between single-units and LFP, and spike-LFP phase-locking were not systematically regulated by dopamine levels. These results demonstrate via causal manipulations that frequency, rather than other properties, is the key property of pathological oscillations in the CBG networks. These insights can lead to improvements in understanding of CBG physiology, PD progression tracking and patient care.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Toward asleep DBS: Cortico basal-ganglia neural activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity 96%
- L-Dopa-induced changes in aperiodic bursts dynamics relate to individual clinical improvement in Parkinson’s disease 94%
- Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson's disease 94%
Similar papers in this journal
- Learning Fast and Slow: Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions 95%
- Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum 95%
- Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation 94%
Similar papers in this journal
- Sensory responses in dorsolateral striatum are modulated by motor activity in a dopamine-dependent manner 95%
- Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease 95%
- Multi-night naturalistic cortico-basal recordings reveal mechanisms of NREM slow wave suppression and spontaneous awakenings in Parkinson's disease 94%
Similar papers in this journal
- Delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb in freely behaving rats 94%
- Dopamine influences attentional rate modulation in Macaque posterior parietal cortex 94%
- The deep and slow breathing characterizing rest favors brain respiratory-drive 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.