Identification of eight SARS-CoV-2 ORF7a deletion variants in 2,726 clinical specimens
Rosenthal, S. H.; Kagan, R. M.; Gerasimova, A.; Anderson, B.; grover, D.; Hua, M.; Owen, R.; Lacbawan, F.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF7a, the ortholog of SARS-CoV ORF7a, is a type I transmembrane protein and plays an important role in virus-host interactions. Deletion variants in ORF7a may influence virulence, but only a few such isolates have been reported. Here, we report 8 unique ORF7a deletion variants of 6 to 96 nucleotides in length identified from 2,726 clinical specimens collected in March of 2020.
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