Mechanisms of antibody binding revealed by asymmetric Fab-virus complexes
Goetschius, D. J.; Hartmann, S. R.; Organtini, L. J.; Callaway, H.; Huang, K.; Bator, C. M.; Ashley, R. E.; Makhov, A. M.; Conway, J. F.; Parrish, C. R.; Hafenstein, S. L.
Show abstract
Overlap on the surface of parvovirus capsids between the antigenic epitope and the receptor binding site contributes to species jumping. Mab 14 strongly binds and neutralizes canine, but not feline parvovirus. The high resolution map of the canine parvovirus capsid complexed with Fab 14 was used to solve local structures of the Fab-bound and -unbound antigenic sites extracted from the same complex. The subsequent analysis includes a new method for using cryo EM to investigate complementarity of antibody binding.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus 97%
- Antibody recognition of CD4-induced open HIV-1 Env trimers 97%
- Asymmetric structures and conformational plasticity of the uncleaved full-length human immunodeficiency virus (HIV-1) envelope glycoprotein trimer 97%
Similar papers in this journal
- Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus 97%
- A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system 96%
- Poxviruses package viral redox proteins in lateral bodies and modulate the host oxidative response 95%
Similar papers in this journal
- Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex 96%
- Molecular mechanisms regulating the pH-dependent pr/E interaction in yellow fever virus. 96%
- The C terminus of infectious bursal disease virus (IBDV) VP3 encodes a predicted intrinsically disordered region (IDR), which promotes the formation of cytoplasmic puncta and modulates their physical properties. 96%
Similar papers in this journal
- Dynamic competition for hexon binding between core protein VII and lytic protein VI promotes adenovirus maturation and entry 96%
- Immature HIV-1 assembles from Gag dimers leaving partial hexamers at lattice edges as substrates for proteolytic maturation. 96%
- Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation 96%
Similar papers in this journal
- HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite 96%
- A human monoclonal antibody targeting a conserved pocket in the SARS-CoV-2 receptor-binding domain core 96%
- Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.