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LncRNA H19X is required for placenta development and angiogenesis through regulating a noncoding RNA regulatory network

Li, T.; Cao, Y.; Zou, Y.; Ye, Y.; Wang, K.; Huang, G.; Li, X.; Zheng, R.; Tang, L.; Lv, J.; Yang, M.; He, J.; Zhang, X.; Bai, S.; Li, Q.; Qin, L.; Zhao, X. M.; Xu, W.

2020-11-20 developmental biology
10.1101/2020.11.19.389940 bioRxiv
Show abstract

H19X is a lncRNA specifically expressed in the placenta, whose expression is induced by hypoxia. H19X overexpression promoted trophoblast proliferation and invasion, while its knockdown or knockout inhibited trophoblast proliferation and invasion. Mechanistically, we demonstrated that reciprocal regulation exists with miR-424/miR-503 in the control of genes related to placental development and angiogenesis, including VEGF and VEGFR2. H19X inhibited ubiquitination of PIWIL1, thereby maintaining its stability and homeostatic expression of piRNAs. PIWIL1 overexpression rescued the defects of cell behavior caused by H19X KO. H19X deletion led to compromised HIF-1A/HIF-2A expression, which was correlated with the dysregulation of downstream genes under hypoxic conditions. CRISPR/Cas-9 knockout of H19X in animals led to defective placenta differentiation and compromised embryo development under hypoxic conditions. Western blotting showed reduced expression levels of PIWIL1 as well as angiogenesis marker genes, including VEGF and VEGFR2, in H19X KO mice. Thus, this study provides evidence of an unexpected link among lncRNA, miRNA, PIWIL1-related piRNA, and angiogenesis in placentation, the dysregulation of which leads to poor placental development and embryo loss under hypoxic conditions.

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