The single pass membrane protein MRAP2 regulates energy homeostasis by promoting primary cilia localization of the G protein-coupled receptor MC4R
Bernard, A. A.; Ojeda Naharros, I.; Bourgain-Guglielmetti, F.; Ciprin, J.; Yue, X.; Zhang, S.; McDaid, E.; Nachury, M. V.; Reiter, J.; Vaisse, C.
Show abstract
The G protein-coupled receptor MC4R (Melanocortin-4 Receptor) and its associated protein MRAP2 (Melanocortin Receptor-Associated Protein 2) are both essential for the regulation of food intake and body weight in humans and mice. MC4R localizes and functions at the neuronal primary cilium, a microtubule-based organelle that senses and relays extracellular signals. Here, we demonstrate that MRAP2 is critical for the ciliary localization and weight-regulating function of MC4R. Our data reveal that GPCR localization to primary cilia can require specific accessory proteins that may not be present in heterologous cell systems. Our findings also demonstrate the essential role of neuronal primary cilia localization of MC4R for adequate control of energy homeostasis and the obesity-promoting effect of genetic disruption of this pathway.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons 95%
- Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling 95%
- The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression 95%
Similar papers in this journal
- TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits 96%
- Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture 95%
- Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin's hunger-suppressing effects 95%
Similar papers in this journal
- Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation 95%
- Astrocyte modulation of synaptic plasticity mediated by activity-dependent Sonic hedgehog signaling 94%
- Synchronicity in zebrafish locomotive circuit development mediated by electrical pacemaker interneurons 94%
Similar papers in this journal
- Cell autonomous regulation of the activation of AgRP neurons by the melanocortin-3 receptor 95%
- Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release 94%
- Nausea-induced suppression of feeding is mediated by central amygdala Dlk1 expressing neurons 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.