Elevation of Gut-Derived p-Cresol Molecular Networks in Astronauts During Spaceflight Informs Drug Metabolism and Performance
Schmidt, M.; Meydan, C.; Schmidt, C.; Afshinnekoo, E.; Mason, C.
Show abstract
Metabolites produced by enteric microbes may have important effects on astronauts on long-duration missions. The NASA Twins Study provided the most comprehensive multi-scale omics data to date from which to extract molecular features of potential clinical significance to spaceflight. From the multivariate data, we identified an elevation of the uremic toxin p-cresol, which is produced by gut microbial fermentation of dietary tyrosine. p-Cresol has adverse metabolic effects via depletion of the hepatic sulfur pool, which impacts metabolism of drugs, endogenous metabolites, and xenobiotics. Moreover, p-cresol reshapes gut microbial community structure by facilitating survival of species such as clostridia and inhibition of butyrate producers. Spaceflight may also impact the genes responsible for the metabolism of p-cresol (e.g. SULT) and for the safe metabolism of common drugs used in space, such as acetaminophen (e.g. SULT, CYP4502E1, GST). Understanding p-cresol production and its related molecular networks in astronauts may lead to precision medicine advances that enhance astronaut safety and performance on long-duration missions.
Matching journals
The top 13 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism 92%
- Bacteria isolated from bengal cat (Felis catus x Prionailurus bengalensis) anal sac secretions produce volatile compounds associated with animal signaling 91%
- Rural Roads to Cognitive Resilience (RRR): A prospective cohort study protocol 91%
Similar papers in this journal
- Time-resolved molecular measurements reveal changes in astronauts during spaceflight 92%
- A Systematic Review on the Effects of Exercise on Gut Microbial Diversity, Taxonomic Composition, and Microbial Metabolites: Identifying Research Gaps and Future Directions 90%
- Stable Potassium Isotopes (41K/39K) Track Transcellular and Paracellular Potassium Transport in Biological Systems 90%
Similar papers in this journal
- Effects of Plastic Ingestion on Blood Chemistry, Gene Expression and Body Condition in Wedge-Tailed Shearwaters (Ardenna Pacifica) 92%
- Chemical patterns of colony membership and mother-offspring similarity in Antarctic fur seals are reproducible over time 92%
- Succession of bacterial communities on carrion is independent of vertebrate scavengers 89%
Similar papers in this journal
Similar papers in this journal
- Molecular Acclimation of Halobacterium salinarum to Halite Brine Inclusions 91%
- SARS-CoV-2 virus in Raw Wastewater from Student Residence Halls with concomitant 16S rRNA Bacterial Community Structure changes 91%
- COVID-19 Trends at The University of Tennessee: Predictive Insights from Raw Sewage SARS-CoV-2 Detection and Evaluation and PMMoV as an Indicator for Human Waste 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.