Worrying drives cell migration in mechanically unrestrained environments
Welf, E. S.; Driscoll, M. K.; Sapoznik, E.; Murali, V. S.; Weems, A. D.; Roh-Johnson, M.; Dean, K. M.; Fiolka, R. P.; Danuser, G.
10.1101/2020.11.09.372912 bioRxivShow abstract
Migratory cells often encounter crowded microenvironments through which they must find or make a path. Amoeboid cells are thought to find a path by deforming their bodies to squeeze through tight spaces. Yet many amoeboid cells seem to maintain a near spherical morphology as they move. To examine this unexplored mechanism of migration, we visualized amoeboid melanoma cells in dense environments and found that they carve a path via bleb-driven mechanical degradation of extracellular matrix components without proteolytic degradation. Interactions between adhesions and collagen at the cell front induce a signaling cascade that promotes bleb enlargement via branched actin polymerization. Large blebs abrade collagen, creating feedback between extracellular matrix structure, cell morphology and polarization that enables both path generation and persistent movement.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner 96%
- After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells 96%
- Cell-type specific mechanical response and myosin dynamics during retinal lens development in Drosophila 96%
Similar papers in this journal
- Optogenetic control of mechanotransduction based on light-induced homodimerization of talin 97%
- Rear cortex contraction aids in nuclear transit during confined migration by increasing pressure in the cell posterior 96%
- CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge 96%
Similar papers in this journal
- Nuclear deformation causes DNA damage by increasing replication stress 96%
- The activation of INF2 by Piezo1/Ca2+ is required for mesenchymal to amoeboid transition in confined environments 95%
- Rap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell migration in vivo 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.