The H2A.J histone variant contributes to Interferon-Stimulated Gene expression in senescence by its weak interaction with H1 and the derepression of repeated DNA sequences
Mangelinck, A.; Coudereau, C.; Courbeyrette, R.; Ouararhni, K.; Hamiche, A.; Redon, C. E.; Bonner, W. M.; Van Dijk, E.; Derbois, C.; Olaso, R.; Deleuze, J.-F.; Fenaille, F.; Ruebe, C. E.; Thuret, J.-Y.; MANN, C.
Show abstract
The histone variant H2A.J was previously shown to accumulate in senescent human fibroblasts with persistent DNA damage to promote inflammatory gene expression, but its mechanism of action was unknown. We show that H2A.J accumulation contributes to weakening the association of histone H1 to chromatin and increasing its turnover. Decreased H1 in senescence is correlated with increased expression of some repeated DNA sequences, increased expression of STAT/IRF transcription factors, and transcriptional activation of Interferon-Stimulated Genes (ISGs). The H2A.J-specific Val-11 moderates the transcriptional activity of H2A.J, and H2A.J-specific Ser-123 can be phosphorylated in response to DNA damage with potentiation of its transcriptional activity by the phospho-mimetic S123E mutation. Our work demonstrates the functional importance of H2A.J-specific residues and potential mechanisms for its function in promoting inflammatory gene expression in senescence.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Hypoxia increases the methylated histones to prevent histone clipping and redistribution of heterochromatin during Raf-induced senescence 96%
- Rapid degradation of Histone Deacetylase 1 (HDAC1) reveals essential roles in both gene repression and active transcription 95%
- Actin nucleators safeguard replication forks by limiting nascent strand degradation 95%
Similar papers in this journal
- Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence 96%
- RAD18 opposes transcription-associated genome instability through FANCD2 recruitment 95%
- tRNA Biogenesis and Specific Aminoacyl-tRNA Synthetases Regulate Senescence Stability Under the Control of mTOR 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.