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Tracking cytosine depletion in SARS-CoV-2

Luo, R.; Wong, Y.-S.; Lam, T.-W.

2020-10-26 bioinformatics
10.1101/2020.10.26.354787 bioRxiv
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MotivationDanchin et al. have pointed out that cytosine drives the evolution of SARS-CoV-2. A depletion of cytosine might lead to the attenuation of SARS-CoV-2. ResultsWe built a website to track the composition change of mono-, di-, and tri-nucleotide of SARS-CoV-2 over time. The website downloads new strains available from GISAID and updates its results daily. Our analysis suggests that the composition of cytosine in coronaviruses is related to their reported mortality. Using 137,315 SARS-CoV-2 strains collected in ten months, we observed cytosine depletion at a rate of about one cytosine loss per month from the whole genome. AvailabilityThe website is available at http://www.bio8.cs.hku.hk/sarscov2/. Contactrbluo@cs.hku.hk Supplementary informationSupplementary data are available at Bioinformatics online.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.