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Genome-wide interaction study implicates VGLL2 and alcohol exposure and PRL and smoking in orofacial cleft risk

2020-10-27 genetic and genomic medicine Title + abstract only
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Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect, affecting approximately 1 in 700 births. NSCL/P has complex etiology including several known genes and environmental factors; however, known genetic risk variants only account for a small fraction of the heritability of NSCL/P. It is commonly suggested that gene-by-environment (GxE) interactions may help explain some of the "missing" heritability of NSCL/P. We conducted a genome-wide GxE interaction study in ...

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