Evidence of antigenic imprinting in sequential Sarbecovirus immunization
Lv, H.; So, R. T. Y.; Yuan, M.; Liu, H.; Lee, C.-C. D.; Yip, G. K.; Ng, W. W.; Wilson, I. A.; Peiris, J. S. M.; Wu, N. C.; Mok, C. K. P.
Show abstract
Antigenic imprinting, which describes the bias of antibody response due to previous immune history, can influence vaccine effectiveness and has been reported in different viruses. Give that COVID-19 vaccine development is currently a major focus of the world, there is a lack of understanding of how background immunity influence antibody response to SARS-CoV-2. This study provides evidence for antigenic imprinting in Sarbecovirus, which is the subgenus that SARS-CoV-2 belongs to. Specifically, we sequentially immunized mice with two antigenically distinct Sarbecovirus strains, namely SARS-CoV and SARS-CoV-2. We found that the neutralizing antibodies triggered by the sequentially immunization are dominantly against the one that is used for priming. Given that the impact of the background immunity on COVID-19 is still unclear, our results will provide important insights into the pathogenesis of this disease as well as COVID-19 vaccination strategy.
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