A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes
Coelho, C. H.; Tang, W. K.; Burkhardt, M.; Galson, J. D.; Muratova, O.; Salinas, N.; Alves e Silva, T. L.; Reiter, K.; MacDonald, N.; Nguyen, V.; Byrne-Steele, M.; Pan, W.; Hou, X.; Brown, B.; Eisenhower, M.; Han, J.; Jenkins, B.; Doritchamou, J. Y. A.; Smelkinson, M.; Vega-Rodriguez, J.; Truck, J.; Sagara, I.; Renn, J.; Tolia, N.; Duffy, P.
Show abstract
Malaria elimination requires tools that interrupt parasite transmission. Here, we characterized B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230kDa gamete surface protein Pfs2301-3 to neutralize sexual stage P. falciparum parasites and halt their further spread. We generated nine Pfs230 human monoclonal antibodies (mAbs). One mAb potently blocked transmission to mosquitoes in a complement-dependent manner and reacted strongly to gamete surface while eight mAbs showed only low or no blocking activity. This study provides a rational basis to improve malaria vaccines and develop therapeutic antibodies for malaria elimination.
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