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Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report.

Goldman, J. D.; Wang, K.; Roltgen, K.; Nielsen, S. C. A.; Roach, J. C.; Naccache, S. N.; Yang, F.; Wirz, O. F.; Yost, K. E.; Lee, J.-Y.; Chun, K.; Wrin, T.; Petropoulos, C. J.; Lee, I.; Fallen, S.; Manner, P. M.; Wallick, J. A.; Algren, H. A.; Murray, K. M.; Su, Y.; Hadlock, J.; Jeharajah, J.; Berrington, W. R.; Pappas, G. P.; Nyatsatsang, S. T.; Greninger, A. L.; Satpathy, A. T.; Pauk, J. S.; Boyd, S. D.; Heath, J. R.

2020-09-25 infectious diseases
10.1101/2020.09.22.20192443 medRxiv
Show abstract

Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a new strain harboring the spike variant D614G. With antibody and B cell analytics, we show correlates of adaptive immunity, including a differential response to D614G. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.

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The top 8 journals account for 50% of the predicted probability mass.

1
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4.1%
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◐ 202 papers in training set
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10
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12
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18
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1.4%
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1.4%
20
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21
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22
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23
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24
The Lancet Infectious Diseases
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Top 0.9%
1.1%
25
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1.1%
26
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Top 1%
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27
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● 179 papers in training set
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1.0%
28
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Top 2%
0.9%
29
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◐ 155 papers in training set
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30
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.